Lipid droplets (LDs) are energy storage organelles composed of neutral lipids, such as triacylglycerol (TG) and sterol esters, surrounded by a phospholipid (PL) monolayer. Their central role in metabolism, complex life cycle, and unique lipid monolayer surface have
Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion.
The increased energy demand is met by the mobilization of energy-rich compounds stored in the liver (glycogen; for acute energy supply for a short period) and adipose tissue (TG; energy...
This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well as how these pathway ys communicate, how they affect lipid metabolism and energy homeostasis in cells and how their dysfunction affects the pathogenesis of lipid storage and lipid metabolism diseases.
Lipid droplet (LD) is the subcellular organelle that stores energy in the form of neutral lipids and releases fatty acids under energy deficient conditions. Energy storage capacity of LDs is primarily dependent on the sizes of LDs. Enlargement and growth of LDs is controlled by two molecular pathways: neutral lipid synthesis and atypical LD fusion.
We study how lipids are stored as neutral lipids in cytosolic lipid droplet organelles. Specifically, we investigate and will present our work on the physical and molecular processes that govern the synthesis of energy storage lipids as well as their storage in and
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important for energy metabolism. Their function in energy storage is firmly established and increasingly well characterized.
All living organisms require a form of energy to sustain life. Whereas the basic mechanisms for powering the life-sustaining anabolic chemical reactions through the high energy bonds of ATP and similar molecules are common to animals and plants, the primary
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