Diet-regulated production of PDGFcc by macrophages controls energy storage. Publication Type: Journal Article: Year of Publication: 2021: PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are
Sep 3, 2021· At the organismal level upon PDGFcc blockade, excess lipids are redirected toward thermogenesis in brown fat. These data identify a macrophage-dependent mechanism,
Jul 7, 2021· PDGFcc production is regulated by diet, and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon
Diet-regulated production of PDGFcc by macrophages controls energy storage. Publication Type: Journal Article: Year of Publication: 2021: PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are
The mechanisms by which macrophages regulate energy storage remain poorly understood. produced by adipose tissue-resident macrophages, controls lipid storage in adipocytes in a leptin receptor- and C-C chemokine receptor type 2-independent manner. PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage
Notably, macrophage production of PDGFcc is regulated by diet and acts through paracrine mechanisms, independent of leptin receptor-and C-C chemokine receptor type 2 (CCR2) signalling, to control
Diet-regulated production of PDGFcc by macrophages controls energy storage. Academic Article Overview abstract PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are redirected toward
Aug 16, 2022· Cox N, Crozet L, Holtman IR, Loyher PL, Lazarov T, White JB, Mass E, Stanley ER, Elemento O, Glass CK, Geissmann F (2021) Diet-regulated production of PDGFcc by macrophages controls energy storage. Science 373:eabe9383. Article CAS PubMed Google Scholar Crozatier M, Meister M (2007) Drosophila haematopoiesis. Cell Microbiol 9:1117–1126
RESEARCH ARTICLE IMMUNOMETABOLISM Diet-regulated production of PDGFcc by macrophages controls energy storage Nehemiah Cox 1†, Lucile Crozet 1,2†, Inge R. Holtman3, Pierre-Louis Loyher,Tomi Lazarov, Jessica B.White2, Elvira Mass1,4, E. Richard Stanley5, Olivier Elemento6,7, Christopher K. Glass3, Frederic Geissmann1,2* The mechanisms by
Diet-regulated production of PDGFcc by macrophages controls energy storage. Nehemiah Cox, Lucile Crozet, Inge R Holtman, Pierre-Louis Loyher, Tomi Lazarov, Jessica B White, Elvira Mass, E Richard Stanley, Olivier Elemento, Christopher K Glass, Frederic Geissmann.
We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required
Download scientific diagram | Ccr2-independent macrophages control lipid storage in mouse adipocytes. from publication: Diet-regulated production of PDGFcc by macrophages controls energy storage
Diet-regulated production of PDGFcc by macrophages controls energy storage: Abstract: PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are redirected toward thermogenesis in brown fat.
Feb 1, 2021· The authors show that PDGFcc, a growth factor produced by macrophages, is required for lipid storage in Drosophila and mammalian fat cells. They also demonstrate that
SummaryMacrophages control inflammation in obese animals, and may also directly or indirectly regulate energy storage. In a genetic screen we identify a PDGF-family growth factor, Pvf3, produced by macrophages and required for lipid storage in Drosophila larvae''s fat body cells. We next demonstrate using genetic and pharmacological approaches that Pvf3 ortholog PDGFcc,
Genetic and pharmacological experiments indicate that the mouse Pvf3 ortholog PDGFcc, produced by adipose tissue–resident macrophages, controls lipid storage in adipocytes in a
The mechanisms by which macrophages regulate energy storage remain poorly understood. We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required for lipid storage in fat-body cells of Drosophila larvae. Genetic and pharmacological experiments
Dec 1, 2021· Cox N et al. 2021 Diet-regulated production of PDGFcc by macrophages controls energy storage. 2006 PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells. 2017 HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Exp.
The mechanisms by which macrophages regulate energy storage remain poorly understood. We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required for lipid storage in fat-body cells of Drosophila larvae. Genetic and pharmacological experiments
Jun 15, 2020· Macrophages control inflammation in obese animals, and may also directly or indirectly regulate energy storage. In a genetic screen we identify a PDGF-family growth factor, Pvf3, produced by macrophages and required for lipid
Jul 2, 2021· PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon
Aug 3, 2022· In contrast to white fat that serves as a site for energy storage, thermogenic fat is used by mammals to mediate energy dissipation. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat. Immunol. 2017; 18:665-674. Diet-regulated production of PDGFcc by macrophages controls energy storage
Jul 2, 2021· Diet-regulated production of PDGFcc by macrophages controls energy storage. Abstract 02 Jul 2021; FULL ACCESS; Adipose-resident macrophages control lipid storage in adipocytes through diet-regulated production of PDGF-family growth factors. Abstract. The mechanisms by which macrophages regulate energy storage remain poorly understood. We
Using a combination of genetic and pharmacological approaches, it is found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice. Macrophages: key mediators of fat storage Recent work has suggested that macrophages may regulate
Jun 15, 2020· The authors show that PDGFcc, a growth factor produced by macrophages, is required for lipid storage in adipocytes and adipose tissue. They demonstrate that PDGFcc
Diet-regulated production of PDGFcc by macrophages controls energy storage Nehemiah Cox, Lucile Crozet, Inge R. Holtman, Pierre-Louis Loyher, Tomi Lazarov, Jessica B. White, and littermate controls. (A) Representative images of inguinal white adipose tissues (iWAT) and epidydimal white adipose tissues (eWAT) from 4 -week-old mice with the
Jul 2, 2021· Diet regulates PDGFcc production by adipose tissue resident macrophages. (A) Representative tSNE color coded flow plot (Top) and May-Grunwald Giemsa staining (Bottom)
Aug 19, 2021· Cox, N. et al. Diet-regulated production of PDGFcc by macrophages controls energy storage. Science 373, eabe9383 (2021). Article CAS PubMed Google Scholar
Recent work has suggested that macrophages may regulate adiposity, but the mechanisms underlying this process remain unresolved. Cox et al. report that a macrophage-derived growth factor, Pvf3, and its receptor on fat body cells are needed for lipid storage in fruit fly larvae (see the Perspective by O''Brien and Domingos). The mouse Pvf3 ortholog, PDGFcc, was similarly
Jul 2, 2021· Recent work has suggested that macrophages may regulate adiposity, but the mechanisms underlying this process remain unresolved. Cox et al. report that a macrophage-derived growth factor, Pvf3, and its receptor on fat body cells are needed for lipid storage in fruit fly larvae (see the Perspective by O''Brien and Domingos). The mouse Pvf3 ortholog, PDGFcc,
Fat pads from N= 4 to 9 mice per genotype from publication: Diet-regulated production of PDGFcc by macrophages controls energy storage | Macrophages: key mediators of fat storage Recent work has
Abstract The mechanisms by which macrophages regulate energy storage remain poorly understood. We identify in a genetic screen a platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF)-family ortholog, Pvf3, that is produced by macrophages and is required for lipid storage in fat-body cells of Drosophila larvae.
Download scientific diagram | Macrophage-derived PDGFcc is required for adipocyte hypertrophy in mice. from publication: Diet-regulated production of PDGFcc by macrophages controls energy storage
PDGFcc production is regulated by diet and acts in a paracrine manner to control lipid storage in adipose tissues of newborn and adult mice. At the organismal level upon PDGFcc blockade, excess lipids are redirected toward thermogenesis in brown fat.
Cox N, Crozet L, Holtman IR, Loyher P-L, Lazarov T, White JB et al (2021) Diet-regulated production of PDGFcc by macrophages controls energy storage. Science 373(6550):eabe9383 Cho C-H, Koh YJ, Han J, Sung H-K, Lee HJ, Morisada T et al (2007) Angiogenic role of LYVE-1–positive macrophages in adipose tissue.
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